Chokeberry (×sorbaronia mitschurinii ) extract delays age disturbance of Drosophila melanogaster intestinal barrier

Chokeberry contains a wide range of biologically active substances with potential geroprotective activity. An ethanolic extract chokeberry ×Sorbaronia mitschurinii (ABE) has previously been found to have positive effect on the lifespan Drosophila melanogaster individuals in short-term exposure (two weeks). The present study evaluated effects ABE integrity D. intestinal barrier. This indicator is marker aging many model organisms (nematodes, fish, and flies) its appearance correlates risk age-dependent death. Brilliant Blue FCF, synthetic blue food coloring, was used as an barrier permeability. It that applied before age 2 weeks did not significantly affect males females. However, treatment at 4-5 resulted 3-fold reduction (p < 0.05) females compromised 8 compared untreated same age. Thus, use fruit middle leads delay onset defects